Auxotrophy-Based Detection of Hyperornithinemia in Mouse Blood and Urine
Gyrate atrophy of the choroid and retina (GACR) is a hereditary form of progressive blindness caused by homozygosity for loss-of-function mutations in the ornithine aminotransferase Rolling Trays gene ( Oat ).The high levels of circulating ornithine that lead to ophthalmic symptoms in young adults are also displayed by 2 ornithine aminotransferase